Genetic differences in metabolic pathways affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects. We consider genetics test the essence of do no harm medicine.
There are over 24,000 over the counter and prescription medications which are created with the assumption the entire population is a normal metabolizer; when the fact is nearly 70% of the population has an aberration within the first five major metabolic pathways most drugs use. Our testing covers about 80% of those medications.
The use of genotyping provides you with “invisible” genetic information on a patient’s propensity for a drug reaction which allows you to further objectify each individual’s treatment, prevent toxicity and minimize the risk of harm due to Adverse Drug Reactions (ADR). Our results can be interpreted generally within 60 seconds.
Awareness of the influence of gene variations on patient response to certain drugs can help physicians identify cases in which a patient isn’t responding as anticipated to a drug therapy.
Genetics test the small differences in the genes between different population groups, or some families within a population group, that have built up over the generations can mean that they react differently to medicines. How people absorb, break down and eliminate (metabolize) drugs in the body can also be impacted upon by their genetic information.
For example, some pain relief medications such as codeine require a protein (an enzyme) produced in the liver called CYP2D6 for the drug to be used by the body, break it down and remove it. Variations in the information contained in the CYP2D6 gene determine how much of this enzyme is produced in the liver.
- People who have low levels of the enzyme used to metabolize codeine takes place slowly and so it remains in the body for a longer period of time than if it was metabolized quickly. Slow metabolizes of codeine are more likely to have respiratory side effects.
- People who produce low levels of CYP2D6 in the liver will require smaller doses of the drugs that are eliminated by this enzyme, while fast metabolizes, people who have a lot of the enzyme, will need larger drug doses to get the same effects.