Tag Archives: Metabolic Pathways

Genetics Test

Genetic differences in metabolic pathways affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects. We consider genetics test the essence of do no harm medicine.

There are over 24,000 over the counter and prescription medications which are created with the assumption the entire population is a normal metabolizer; when the fact is nearly 70% of the population has an aberration within the first five major metabolic pathways most drugs use. Our testing covers about 80% of those medications.

The use of genotyping provides you with “invisible” genetic information on a patient’s propensity for a drug reaction which allows you to further objectify each individual’s treatment, prevent toxicity and minimize the risk of harm due to Adverse Drug Reactions (ADR). Our results can be interpreted generally within 60 seconds.

Awareness of the influence of gene variations on patient response to certain drugs can help physicians identify cases in which a patient isn’t responding as anticipated to a drug therapy.

Genetics test the small differences in the genes between different population groups, or some families within a population group, that have built up over the generations can mean that they react differently to medicines. How people absorb, break down and eliminate (metabolize) drugs in the body can also be impacted upon by their genetic information.

For example, some pain relief medications such as codeine require a protein (an enzyme) produced in the liver called CYP2D6 for the drug to be used by the body, break it down and remove it. Variations in the information contained in the CYP2D6 gene determine how much of this enzyme is produced in the liver.

  • People who have low levels of the enzyme used to metabolize codeine takes place slowly and so it remains in the body for a longer period of time than if it was metabolized quickly. Slow metabolizes of codeine are more likely to have respiratory side effects.
  • People who produce low levels of CYP2D6 in the liver will require smaller doses of the drugs that are eliminated by this enzyme, while fast metabolizes, people who have a lot of the enzyme, will need larger drug doses to get the same effects.

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Embryonic stem cells the holy grail of youth and health

How China became the unrivaled leader in stem cell transplantation technology:

As the rest of the world was still discussing moral and religious issues concerning the legality of Embryonic Stem Cell Research, the Government of China pumped billions of dollars of research money into State funded and State sponsored facilities.

This has led to one breakthrough after the other and has made China the unrivaled leader, when it comes to technological advances as well as quality of service of both Stem Cell as well as Immune Cell Therapies.

A. The origin of Embryonic Stem Cells:

The popular opinion that embryos are created in a petry dish in order to harvest its stem cells are far from true. In reality embryonic stem cells are taken from aborted fetuses or fertilized eggs that are left over from in vitro fertilization. Tissues that would otherwise be discarded, none of which would ever become a human being.

B. The answer to a prayer:

These stem cells are now becoming the answer to the prayer of patients otherwise doomed. Once diagnosed with liver or pancreatic cancer a patients one year survival chance with traditional methods is less than 3%, treated with the right amount of embryonic stem cells in a top ranking facility like the Beijing Great Wall International Cancer Center, the survival rate is above 80% for the first year and still 76% after 5 years. Now tell me if this is a worthwhile and moral undertaking?

C. The holy grail of youth and health:

If God has created and shown us the key to longevity, mental and physical health then this holy grail of “eternal” youth is definitely to be found in stem cell transplantation technology.

D. How safe are ESC’s?

Unfortunately few countries have developed the procedures like China to a degree where the patients safety is virtually guaranteed:
1. There have been no known toxic side effects since they started ESC treatments in the Beijing Great Wall International Cancer Center in clinical application in 2003, treating over 10,000 people.
2. All of the Stem Cells are processed under sterile surgical conditions and are only taken from fertilized eggs between 15 and 56 days old.
3. Processing each set of Stem Cells takes two months; during this time they are rigidly genetically tested for infectious diseases, heredity defects and tissue problems to ensure safety in transplantation.
4. Over the two month genetic testing process about 2/3 of Stem Cells are found to be unsuitable for treatments and are discarded.
5. The Stem Cells are frozen at the extremely low temperature of -196° Celsius and stored in liquid nitrogen to ensure their safety and that they do not mutate.
6. The cells are gradually restored to normal body temperature before the transplantation.
7. The patients receive a full range of diagnostic and clinical treatment as well as ongoing medical counseling after the treatment.
8. Stem Cell transplantation is a minimally invasive procedure involving only minor intervention in the patient’s body.
9. Unlike Adult Stem Cells, the Embryonic Cells they use CANNOT be rejected by the patient due to potential incompatibility.

How would you like becoming 80 years old and to look and feel like 35?

By: Alexander Todea